Antibodies have been selected to demonstrate the expression patterns of well-known proteins and to reflect antibodies used in clinical diagnostics to determine the nature of a given cancer. When applicable, the immunofluorescent images are complemented by immunohistochemically stained cells where the location of the particular cell structure is shown in brown.įor the 'Protein expression' section, tissue slides representing both normal and cancer tissue have been stained using immunohistochemistry to visualize various protein expression patterns. The channels can be toggled on and off by clicking on the respective coloured button above the image. The other channels: nucleus, microtubules and endoplasmic reticulum, are always shown in the blue, red and yellow channels, respectively. The antibody name is linked to the subcellular location summary page of the target gene. The various cell structures that are demonstrated are always shown in the green channel using an antibody found in the Human Protein Atlas.
Throughout these sections, arrows indicate relevant tissue structures, cell-types and other features.įor the 'Cell structure' section, immunofluorescent images of formaldehyde-fixed cell lines are shown. Clicking on these boxes will zoom in on that part to show tissue structures, cells and features in greater detail. On the top level, an overview of the whole tissue-sample is shown with boxes in black indicating where zoomed-in representative parts of the tissue are available for viewing. Within each section there are direct links to histology descriptions of different tissue types and tumor forms as well as descriptions of cell structures.įor the 'Tissue & cell types' and 'Tumors' sections, tissue-slides stained with hematoxylin and eosin (HE) are shown at three different levels of magnification. Below the Protein expression section there is a list of genes with links to examples of different protein expression patterns. For the cancer-section there is also a link to current cancer statistics (incidence, survival, etc) for Sweden and the rest of the world. Below the image of each section are links to introductory texts for i) normal tissue histology, ii) hallmarks of cancer, and iii) cell structure overview. On the welcome page of the dictionary, four major sections are shown: Normal tissues, Cancer, Cell structure and Protein expression.
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